EVERCORE

Clinical Applications

Where the Surface Meets Its Scaffold

Where the SurfaceMeets Its Scaffold

From chronic dry eye to acute injury, amniotic membrane therapy gives the cornea the biologic foundation it needs to heal.

The Science of Healing

Epithelial Migration:How Healing Happens

The body's natural process of rebuilding the surface layer — and the biologic environment that helps it happen.

1

Injury Occurs

The surface epithelium is disrupted, creating a defect.

2

Edge Cells Activate

Cells at the wound edge alter their shape, loosen cell junctions, and become motile.

3

Cells Migrate

Activated cells crawl across the wound bed, using the underlying matrix as a scaffold.

4

Cells Attach & Multiply

Once coverage is achieved, cells attach, stabilize, and multiply to strengthen the layer.

5

Wound Closed & Remodeled

The epithelium is fully restored and continues to mature and remodel.

How the Amniotic Disc Supports Migration

Structural Scaffold

Provides a native extracellular matrix that epithelial cells can attach to and move across.

Anti-Inflammatory Environment

Contains cytokines and growth factors that help modulate inflammation, reducing signals that slow migration.

Anti-Scarring Properties

Helps regulate the healing response and may reduce fibrosis and scar tissue formation.

Anti-Microbial Contribution

Contains components that help create a protective environment against microbial growth.*

Promotes Epithelialization

Supports cell adhesion, proliferation, and migration, helping the surface close more efficiently.

* Amniotic membrane is not an antibiotic and does not replace standard infection control.

Amniotic Disc

  • Dehydrated human amniotic membrane allograft
  • Room temperature storage
  • Multiple sizes available
  • Rehydrate in place with sterile saline or water
  • Place on target tissue
  • Secure with bandage, contact lens, or dressing

Key Takeaway

Epithelial migration is how the surface heals. Amniotic discs provide the structure, protection, and biologic environment that support and facilitate this natural process.

Important Safety Information

Potential risks include infection, bleeding, swelling, redness, soft tissue or nerve injury, immune response, or disease transmission. Do not use if packaging is damaged, product is expired, or sterility is compromised. For use by trained healthcare professionals.

Traceability (HCT/P Compliance)

Documentation of donor product to patient is required under FDA 21 CFR 1271.290. The clinician is responsible for maintaining traceability records.

01

Dry Eye Disease

When tears, anti-inflammatories, and punctal occlusion plateau, the ocular surface itself needs repair.

How Amniotic Membrane Helps

  • Acts as a biologic bandage over stained, compromised epithelium
  • Supports epithelial migration across a basement-membrane scaffold
  • Helps quiet the inflammatory cycle that perpetuates surface breakdown
  • Fits within a standard in-office appointment

Clinical Note

Often considered for moderate to severe disease, filamentary keratitis, and patients intolerant of contact lenses due to surface damage.

02

Persistent Epithelial Defects & Corneal Ulcers

Defects that will not close on conventional therapy demand a surface that invites healing.

How Amniotic Membrane Helps

  • Provides immediate protection for exposed stroma
  • Matrix composition mirrors native corneal basement membrane
  • Supports closure in neurotrophic and healing-impaired corneas
  • Reduces the friction of every blink during recovery

Clinical Note

A mainstay of tertiary corneal care, now practical for in-office anterior segment practices.

03

Recurrent Corneal Erosion

Lubrication manages the symptom. It does not rebuild the adhesion that failed.

How Amniotic Membrane Helps

  • Temporary basement-membrane substitute while adhesion regenerates
  • Helps break the cycle of waking pain and recurrent breakdown
  • Pairs naturally with debridement protocols
  • Anti-inflammatory environment supports durable re-epithelialization

Clinical Note

Counsel patients on short-term blur in exchange for fewer recurrences over the months that follow.

04

Post-Surgical Healing

The procedure is only half the outcome. The surface decides the rest.

How Amniotic Membrane Helps

  • Supports re-epithelialization after pterygium excision
  • Comfort and protection following PRK and surface ablation
  • Helps manage conjunctival healing and reduce scarring signals
  • Self-retained formats avoid additional suture placement

Clinical Note

Surgical centers value the dehydrated format's ambient storage and on-demand readiness.

05

Chemical & Thermal Injury Support

In acute surface injury, calming inflammation early shapes the entire healing arc.

How Amniotic Membrane Helps

  • Protects the limbal niche during critical early healing
  • Moderates inflammatory cell activity at the surface
  • Supports epithelial recovery in acute and sub-acute phases
  • Part of a comprehensive acute-care protocol

Clinical Note

Always within a full acute management protocol guided by the treating clinician.

Discuss a Case With Our Team

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